CEPHARANTHINE AS A POTENTIAL NOVEL TUMOR-REGIONAL THERAPY IN TREATING CUTANEOUS MELANOMA: ALTERING THE EXPRESSION OF CATHEPSIN B, TUMOR SUPPRESSOR GENES AND AUTOPHAGY-RELATED PROTEINS

The incidence of primary cutaneous melanoma continues to increase annually and is one of the most aggressive malignancies in humans and need to develop more novel non-surgical therapies.Autophagy and cathepsin B targeted therapy was reported to improve melanoma treatment.Cepharanthine (CEP), a natural alkaloid extracted from the genus Cephalophyllu

Fusarium stalk rot (FSR), a devastating soil-borne disease caused by Fusarium species, severely threatens global maize production through yield losses and mycotoxin contamination.Bacillus subtilis, a plant growth-promoting rhizobacterium (PGPR), has shown potential as a biocontrol agent against soil-borne pathogens, but its efficacy and mechanisms

Objective: To assess the effectiveness of magnesium sulfate as a neuroprotective agent in early preterm labour (28 to 32 weeks).To assess any maternal or fetal adverse effects after giving magnesium sulfate.Methods: Hospital based prospective observational study.Initially 72 pregnant women with preterm labour, planned preterm birth due to maternal